Enhancement of mononuclear procoagulant activity by platelet 12-hydroxyeicosatetraenoic acid.
نویسندگان
چکیده
منابع مشابه
Enhancement of mononuclear procoagulant activity by platelet 12-hydroxyeicosatetraenoic acid.
Platelets induce generation of procoagulant tissue factor activity (TFa) by mononuclear leukocytes, and also enhance the TFa induced by endotoxin. Our present investigation demonstrated that arachidonic acid, which by itself had no effect on mononuclear TFa, greatly enhanced platelet-induced TFa. The effect was concentration dependent for both platelets and arachidonate (1-20 microM); other fat...
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Stimulated platelets, in the presence or absence of aspirin, synthesize significant quantities of 12-hydroxyeicosatetraenoic acid (12-HETE), which is chemotactic and chemokinetic, and enhances mononuclear cell procoagulant activity. During a cell-cell interaction between stimulated platelets and unstimulated neutrophils, platelet 12-HETE is metabolized to 12,20-dihydroxyeicosatetraenoic acid (1...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1986
ISSN: 0021-9738
DOI: 10.1172/jci112592